2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Related Products

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Nucleoside analogues are molecules that act like nucleosides in DNA synthesis. They include a range of antiviral products used to prevent viral replication in infected cells. Nucleoside analogues can be used against hepatitis B virus, hepatitis C virus, herpes simplex, and HIV. Once they are phosphorylated, they work as antimetabolites by being similar enough to nucleotidesto be incorporated into growing DNA strands. Less selective nucleoside analogues are used as chemotherapy agents to treat cancer, eg gemcitabine and 5-FU. Antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. Such substances are often similar in structure to the metabolite that they interfere with, such as the antifolates that interfere with the use of folic acid. The presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer.

Nucleoside Antimetabolite/Analog Related Products (1741):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-111648
    6-O-Methyl Guanosine
    		98.62%
    6-O-Methyl Guanosine is a modified nucleoside. 6-O-Methyl Guanosine (6-methylguanosine) inhibit colony-forming ability in a malignant xeroderma pigmentosum cell line.
    6-O-Methyl Guanosine
  • HY-124143
    Isoguanine
    		99.64%
    Isoguanine is a purine base that is an isomer of Guanine. A building block in organic synthesis.
    Isoguanine
  • HY-13538A
    Gemcitabine elaidate hydrochloride
    		Inhibitor 99.89%
    Gemcitabine elaidate (CP-4126) hydrochloride is lipophilic pro-agent of Gemcitabine. Gemcitabine elaidate hydrochloride is converted to Gemcitabine by esterases in order to be phosphorylated. Gemcitabine elaidate hydrochloride exhibits anti-tumor activity.
    Gemcitabine elaidate hydrochloride
  • HY-W091784
    3'-O-Methylguanosine
    		98.66%
    3'-O-Methylguanosine is a methylated nucleoside analogs and a RNA chain terminator. 3'-O-methylguanosine can inhibit early virus-specific RNA synthesis.
    3'-O-Methylguanosine
  • HY-W002272
    Isocytosine
    		99.71%
    Isocytosine is a non-natural nucleobase and an isomer of cytosine. It is used in combination with Isoguanine in studies of unnatural nucleic acid analogues of the normal base pairs in DNA and used as a nucleobase of hachimoji RNA.
    Isocytosine
  • HY-106934A
    Peldesine dihydrochloride
    		99.63%
    Peldesine (BCX 34) dihydrochloride is a potent, competitive, reversible and orally active purine nucleoside phosphorylase (PNP) inhibitor with IC50s of 36 nM, 5 nM, and 32 nM for human, rat, and mouse red blood cell (RBC) PNP, respectively. Peldesine dihydrochloride is also a T-cell proliferation inhibitor with an IC50 of 800 nM. Peldesine dihydrochloride has the potential for cutaneous T-cell lymphoma, psoriasis and HIV infection research.
    Peldesine dihydrochloride
  • HY-111646
    N6-Etheno 2'-deoxyadenosine
    		99.48%
    N6-Etheno 2'-deoxyadenosine is a reactive oxygen species (ROS)/reactive nitrogen species (RNS)-induced DNA oxidation product, used as a biomarker to evaluate chronic inflammation and lipid peroxidation in animal or human tissues.
    N6-Etheno 2'-deoxyadenosine
  • HY-B1449S
    Uridine-15N2
    		98.00%
    Uridine-15N2 is the 15N labeled Uridine[1].
    Uridine-<sup>15</sup>N<sub>2</sub>
  • HY-45409
    DMT-2′Fluoro-dU Phosphoramidite
    		98.83%
    DMT-2′Fluoro-dU Phosphoramidite could be used for nucleoside modification.
    DMT-2′Fluoro-dU Phosphoramidite
  • HY-B0228R
    Adenosine (Standard)
    		Chemical
    Adenosine (Standard) is the analytical standard of Adenosine. This product is intended for research and analytical applications. Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation.
    Adenosine (Standard)
  • HY-W008388
    Bz-rA
    		99.51%
    Bz-rA (N6-Benzoyladenosine) is a N6-protected adenosine that can be used to synthesize oligoribonucleotides.
    Bz-rA
  • HY-W006102
    Bz-rA Phosphoramidite
    		99.03%
    Bz-rA Phosphoramidite is used for ribonucleotides modification.
    Bz-rA Phosphoramidite
  • HY-13672
    LY2334737
    		Inhibitor 98.88%
    LY2334737 is an nucleoside analog and is an orally active proagent of Gemcitabine. LY2334737 exhibits inhibitory activity against enterovirus A71 (EV-A71) infection. LY2334737 has antiviral and anticancer effects.
    LY2334737
  • HY-W251687
    2'-Deoxy-2'-fluoroarabinoadenosine
    		99.92%
    2'-Deoxy-2'-fluoroarabinoadenosine is a nucleoside analogue, which exhibits anticancer activity against human immunodeficiency virus (HIV).
    2'-Deoxy-2'-fluoroarabinoadenosine
  • HY-19743
    Triazavirin
    		99.15%
    Triazavirin is a nucleoside analogue of nucleic acid and an antiviral agent. Triazavirin works by inhibiting the synthesis of viral RNA and DNA and replication of genomic fragments. Triazavirin is also an effective protective agent on the transmission stage of influenza.
    Triazavirin
  • HY-16445
    Sapacitabine
    		Chemical 98.13%
    Sapacitabine is an orally available nucleoside analog proagent that is structurally related to cytarabine.
    Sapacitabine
  • HY-W115186
    DMT-2'-OMe-Bz-C
    		99.11%
    DMT-2'-OMe-Bz-C is a cytidine analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities.
    DMT-2'-OMe-Bz-C
  • HY-W114787
    N4-Benzoyl-2’-O-methylcytidine
    		99.26%
    N4-Benzoyl-2’-O-methylcytidine is a cytidine analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities.
    N4-Benzoyl-2’-O-methylcytidine
  • HY-111639
    2’-O,4’-C-Methyleneuridine
    		99.57%
    2’-O,4’-C-Methyleneuridine (Compound 15a) is a bicyclic nucleoside.
    2’-O,4’-C-Methyleneuridine
  • HY-B0228S
    Adenosine-d
    		Chemical 99.72%
    Adenosine-d is the deuterium labeled Adenosine. Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation[1][2].
    Adenosine-d